Basic Medical Science Department Head

Dr. Nirmin Alsahafi

Assistance Professor of Microbiology

Qualifications & Specialty  

• Bachelor with honors in Microbiology from King Abdulaziz University.
• Granted a Master’s and a Doctorate in Microbiology & Immunology from McGill University, Montreal, Canada.
• Completed a postdoctoral fellowship in Chronic Viral Infections, Oncology, & Immunotherapy at Princess Margret Cancer Center, University Health Network (UHN), University of Toronto, Toronto- Canada (2019-2021).

Publications

Dr. Alsahafi has well-cited publications  in high-impact journals :

Snell LM, Xu W, Abd-Rabbo D, Boukhaled G, Guo M, Macleod BL, Elsaesser HJ, Hezaveh K, Alsahafi N, Lukhele S, Nejat S, Prabhakaran R, Epelman S, McGaha TL, Brooks DG. Dynamic CD4+ T cell heterogeneity defines subset-specific suppression and PD-L1-blockade-driven functional restoration in chronic infection. Nat Immunol. (12):1524-1537(2021)

Alsahafi N, Bakouche N, Kazemi M, Richard J, Ding S, Bhattacharyya S, Das D, Anand SP, Prévost J, Tolbert WD, Lu H, Medjahed H, Gendron-Lepage G, Ortega Delgado GG, Kirk S, Melillo B, Mothes W, Sodroski J, Smith AB 3rd, Kaufmann DE, Wu X, Pazgier M, Rouiller I, Finzi A, Munro JB. An Asymmetric Opening of HIV-1 Envelope Mediates Antibody-Dependent Cellular Cytotoxicity. Cell Host Microbe5(4):578-587 (2019).

Lu M, Ma X, Castillo-Menendez LR, Gorman J, Alsahafi N, Ermel U, Terry DS, Chambers M, Peng D, Zhang B, Zhou T, Reichard N, Wang K, Grover JR, Carman BP, Gardner MR, Nikić-Spiegel I, Sugawara A, Arthos J, Lemke EA, Smith AB 3rd, Farzan M, Abrams C, Munro JB, McDermott AB, Finzi A, Kwong PD, Blanchard SC, Sodroski JG, Mothes W. Associating HIV-1 envelope glycoprotein structures with states on the virus observed by smFRET. Nature 568(7752):415-419 (2019).

Jin SW, Alsahafi N, Kuang XT, Swann SA, Toyoda M, Göttlinger H, Walker BD, Ueno T, Finzi A, Brumme ZL, Brockman MA. Natural HIV-1 Nef Polymorphisms Impair SERINC5 Downregulation Activity. Cell Report29(6):1449-1457 (2019)

Nguyen HT, Alsahafi N, Finzi A, Sodroski JG. Effects of the SOS (A501C/T605C) and DS (I201C/A433C) Disulfide Bonds on HIV-1 Membrane Envelope Glycoprotein Conformation and Function. Journal of Virology 93(12). pii: e00304-19 (2019).

Alsahafi N, Anand SP, Castillo-Menendez L, Verly MM, Medjahed H, Prévost J, Herschhorn A, Richard J, Schön A, Melillo B, Freire E, Smith AB 3rd, Sodroski J, Finzi A. SOSIP Changes Affect Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Conformation and CD4 Engagement. Journal of Virology(19). pii: e01080-18 (2018)

 Richard J, Prévost J, Alsahafi N, Ding S, Finzi A. Impact of HIV-1 Envelope Conformation on ADCC Responses. Trends Microbiology (4):253-265 (2018).

Alsahafi N, Richard J, Prévost J, Coutu M, Brassard N, Parsons MS, Kaufmann DE, Brockman M, Finzi A. Impaired Downregulation of NKG2D Ligands by Nef Proteins from Elite Controllers Sensitizes HIV-1-Infected Cells to Antibody-Dependent Cellular Cytotoxicity. Journal of Virology

91(16). pii: e00109-17 (2017).

Pacheco B, Alsahafi N, Debbeche O, Prévost J, Ding S, Chapleau JP, Herschhorn A, Madani N, Princiotto A, Melillo B, Gu C, Zeng X, Mao Y, Smith AB 3rd, Sodroski J, Finzi A. Residues in the gp41 Ectodomain Regulate HIV-1 Envelope Glycoprotein Conformational Transitions Induced by gp120-Directed Inhibitors. Journal of Virology(5). pii: e02219-16 (2017)

Baxter AE, Niessl J, Fromentin R, Richard J, Porichis F, Massanella M, Brassard N, Alsahafi N, Routy JP, Finzi A, Chomont N, Kaufmann DE. Multiparametric characterization of rare HIV- infected cells using an RNA-flow FISH technique. Nature Protocol(10):2029-2049 (2017).

Tolbert WD, Gohain N, Alsahafi N, Van V, Orlandi C, Ding S, Martin L, Finzi A, Lewis GK, Ray K, Pazgier M. Targeting the Late Stage of HIV-1 Entry for Antibody-Dependent Cellular Cytotoxicity: Structural Basis for Env Epitopes in the C11 Region. Structure 25(11):1719-1731 (2017)

Richard J, Veillette M, Ding S, Zoubchenok D, Alsahafi N, Coutu M, Brassard N, Park J, Courter JR, Melillo B, Smith AB 3rd, Shaw GM, Hahn BH, Sodroski J, Kaufmann DE, Finzi A. Small CD4 Mimetics Prevent HIV-1 Uninfected Bystander CD4 + T Cell Killing Mediated by Antibody- dependent Cell-mediated Cytotoxicity. EBioMedicine9;3:122-134 (2016).

Baxter AE, Niessl J, Fromentin R, Richard J, Porichis F, Charlebois R, Massanella M, Brassard N, Alsahafi N, Delgado GG, Routy JP, Walker BD, Finzi A, Chomont N, Kaufmann DE. Single-Cell Characterization of Viral Translation-Competent Reservoirs in HIV-Infected Individuals. Cell Host Microbe 20(3):368-380 (2016).

Richard J, Pacheco B, Gohain N, Veillette M, Ding S, Alsahafi N, Tolbert WD, Prévost J, Chapleau JP, Coutu M, Jia M, Brassard N, Park J, Courter JR, Melillo B, Martin L, Tremblay C, Hahn BH, Kaufmann DE, Wu X, Smith AB 3rd, Sodroski J, Pazgier M, Finzi A. Co-receptor Binding Site Antibodies Enable CD4-Mimetics to Expose Conserved Anti-cluster A ADCC Epitopes on HIV-1 Envelope Glycoproteins. EBioMedicine12:208-218 (2016).

Alsahafi N, Ding S, Richard J, Markle T, Brassard N, Walker B, Lewis GK, Kaufmann DE, Brockman MA, Finzi A. Nef Proteins from HIV-1 Elite Controllers Are Inefficient at Preventing Antibody- Dependent Cellular Cytotoxicity. Journal of Virology90(60): 2993-3002 (2015).

Alsahafi N, Debbeche O, Sodroski J, Finzi A. Effects of the I559P gp41 change on the conformation and function of the human immunodeficiency virus (HIV-1) membrane envelope glycoprotein trimer. PLoSOne0(4):e0122111(2015).

Research Interest

Dr. Alsahafi is interested in uncovering the interplay of diagnostic immune biomarkers in chronic infections & cancer and the development of immunotherapy

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Dr. Ehab Aboueladab

Associate Professor of Biochemistry

Qualifications & Specialty  

Associate Professor  Of Biochemistry,                                           2012-Present

Doctoral (PhD) in Biochemistry, 2006

Cairo University, Faculty of Science,                                             2002-2006

Specialization: Biochemistry

Master of Biochemistry, 1994

Mansoura University, Faculty of Science,                                   1991 – 1994

Specialization: Biochemistry

Bachelor of Chemistry, 1990                                                       

Mansoura University, Faculty of Science

Specialization: Chemistry

MSc. Title: Isolation and Characterization of Buffalo Chymosin.

PhD. Title: Galectin-1 Stimulated Signaling Events in T- Lymphocytes.

Publications

Books

1-Buffalo Chymosin: Preparation of Buffalo Chymosin by Ehab Aboueladab and Camellia Abdel Malak (May 4, 2012)

2-Expression of CD20, CD27 positive B lymphocyte in Rheumatoid Arthritis: Immunochemical detection of Cluster of… by Walaa Fikry Elbossaty, Ehab Aboueladab and Ali Yousef (Feb 27, 2011)

3-Galectin-1 and apoptosis: Induction of apoptosis in galectin-1 stimulated Jurkat T lymphocytes by Ehab Aboueladab (May 7, 2010)

http://www.amazon.com/s/ref=nb_sb_noss?url=search-alias%3Daps&field-keywords=aboueladab

Scientific Production

1- CA Abdel Malak, IF Abou El Adab, V Vukashinovic, IA Zalunin, EA Timokhina, GI Lavrenova, and VM Stepanov (1996). Buffalo (Bos buffali L.) Chymosin purification and properties. Comp Biochem Physiol B Biochem Mol Biol, 113(1): 57-62.  http://www.ncbi.nlm.nih.gov/pubmed/8936042

2- Hermann Walzel, Abdelgawad A. Fahmi, Mohamed A. Eldesouky, Ehab F. Abou-Eladab, Grit Waitz, Josef Brock, and Markus Tiedge (2006). Effects of N-glycan processing inhibitors on signaling events and induction of apoptosis in galectin-1 stimulated Jurkat T lymphocytes. Glycobiology, 16:1262-1271

3- Bettina Brandt • Tom Büchse • Ehab Fathi Abou-Eladab. Markus Tiedge • Eberhard Krause • Udo Jeschke • Hermann Walzel (2008). Galectin-1 induced activation of the apoptotic death-receptor pathway in human Jurkat T lymphocytes. Histochem Cell Biol, 129(5):599-609

4- B Brandt, E F Abou-Eladab, M Tiedge, and H Walzel (2010). Role of the JNK/c-Jun/AP-1 signaling pathway in galectin-1-induced T-cell death. Cell Death and Disease

5- Sahloul, T.M, H.M. Emara, F.E.El deeb, E.F. abou Eladab, Dina H.Elbushuty (2010). Cultivation of mushroom using the environement residues at home and maximizing the utilization of nutrition and health. Journal of Agricultural chemistry and biotechnology, vol 1 No (3):157-168

6- Mohammed. R.Mostafa, Ali.M.E.Yousef, Ehab.F.Abou-Eladab, Fatemah.A.Elshabacy, Walaa Fikry Elbossaty (2010). Expression of CD20 versus CD27 positive B-lymphocyte in rheumatoid arthritis. Egypt Rheumatol Rehab, Vol. 37, No. 3, July, 2010

7- Medicharla V. Jagannadham, Ehab.F.Abou-Eladab, Heramb M.kularni (2011). Identification of outer membrane proteins from an Antarctic bacterium pseudomonas syringae Lz4W, Molecular and cellular proteomics. http://www.mcponline.org/content/10/6/M110.004549.full.pdf

8-Ehab F. Abou-Eladab, M Mohammed Idris, Medicharla V Jagannadham (2012). Evaluation of protein preparations from bacteria using proteomics approaches: Application to an Antarctic bacterium Pseudomonas syringae. Nature and Science 10(4): 102-114

9- Mohamed Ahmed Hassanien, Saad-El-Din Abd-El-Fattah Abou-El-Noeman and Ehab Aboueladab (2014). Oxidative Stress, Antioxidant and Leptin Status in Patients with Nonalcoholic Steatohepatitis. Journal European Journal of Academic Essays. Volume 10, Issue 1, Pages 17-22

10-Ehab Aboueladab, Faten Shehata and Shawgi albahari (2015). Separation, Identification and characterization of proteins by Novel techniques and application. European Journal of Academic Essays 2(8): 34-40.

11- Ehab Abou-eladab, Faten Shehata and Shawgi Albahari (2015). Roles Biomarkers in Basic and Clinical Research for Breast Cancer. Archives in Cancer Research. 3(4):1-18

12-Ehab Aboueladab, Faten Shehata (2016).

Biomarkers, Methods for Detection and Treatment of Breast Cancer.

International Journal of Advanced Research. Volume 4, Issue 4, 1180-1191

13-Ehab Abou-Eladab, Faten Shehata and Shawgi albahari. (2016).

Vitamin D deficiency and Associated Dental Caries (Review).

International Journal of Advanced Research (2016), Volume 4, Issue 5, 1239-1246

14-Ehab Abou-eladab, Heba Abd Alrazzak abd Alfattah, and Faten Shehata. (2016)

Impact of Sildenafil on Smooth Muscle and Blood Vessels by Using Light and Electron Microscopy.

British Journal of Medicine and Medical Research 16 (8), 1-9

15-A Cross-sectional Study of Iron Deficiency Anemia and Hemoglobinopathy Carriers among School Children in Two Different Cities in KSA-Open Access Macedonian Journal of Medical Sciences 2022

16-COVID-19 Immunization Perceptions and Acceptance among Dental School Health Care Employees             

EC Dental Science 2022

17-Oral Cancer Diagnosis: Protein Biomarkers Role (Review)              Journal of Cancer Research & Clinical Practice 2023

Research Interest

Biochemistry – Cancer disease – Proteomics-cell signaling – Nutrition

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Dr. Abdelhamid Gaber Abdelhamid Amer

Assistant Professor of Pharmacology

Qualifications & Specialty  

Obtained a Bachelor of Medicine and Surgery from the Faculty of Medicine, Menoufia University in the Arab Republic of Egypt in 1998

Dr. Abdelhamid obtained a master’s degree in clinical pharmacology from Menoufia University in the Arab Republic of Egypt in (2004)

Also obtained a master’s degree in anesthesiology and intensive care from Al-Azhar University in the Arab Republic of Egypt in 2006

Completed his specialization in clinical pharmacology by obtaining a doctorate from Menoufia University in the Arab Republic of Egypt in 2013.

Research Interest

In the field of drug science and its modern and new trend applications

Publications

Dr. Abdelhamid has many International researches in his field of specialization.

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Dr. Amr Zewail

Assistant Professor of Anatomy

Qualifications & Specialty  

• Medical Doctorate (M.D.) Anatomy and Embryology, Faculty of Medicine Ain Shams University, 2014
• Master’s degree (M.Sc.) Anatomy and Embryology, Faculty of Medicine Ain- Shams University, 2008.
• Subsidiary Biochemistry, Ain-Shams University, 2005.
• Bachelor of Medicine and Surgery (M.B.B. Ch.), Cairo University, December 1998.

Publications

• Alterations in Inflammatory Markers and Cognitive Ability after Treatment of Pediatric Obstructive Sleep Apnea Medicina 2023, 59, 204 https://doi.org/10.3390/medicina59020204.
• Recurrent respiratory infections and vitamin A level: a link? It is cross-sectional. Medicine 2022; 101:33(e30108) http://dx.doi.org/10.1097/MD.0000000000030108.
• Evaluation of osteogenic potential of Cissus. “Quadrangularis on mandibular alveolar ridge. BMC(2021) 21:4 https://doi.org/10.1186/s12903-021-01847-y
• MD thesis: Anatomical variations of uncinate process of the ethmoid bone with reference to clinical applications, Ain Shams University, 2013.
• Master’s thesis: Morphological and morphometric study of the Sacroiliac joint in human, Ain Shams University, 2007.

Research Interest

Applied Anatomy

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 Dr. Heba Kamal Mahrous Bayoumi

Assistant Professor of Microbiology

Qualifications & Specialty  

Obtained a bachelor’s degree in microbiology from Alexandria University from the Faculty of Science in the Arab Republic of Egypt in 1992.

Dr. Mahrous also obtained a master’s degree from Alexandria University in the Arab Republic of Egypt in 1998

The doctor completed her specialty by obtaining a doctorate from Alexandria University in the Arab Republic of Egypt in 2005.

Publications:

• Ghanem N B Yusef H H and Mahrouse H. K 2000. Production of Aspergillus terreus xylanase in solid state culture application of Plackett Burman experimental design to evaluate nutritional requirement bioresource technology, 73:113–121.

Research Interest:

Bacterial diseases and molecular genetics

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Ghada Al-Habbab

Lecturer in the Department of Basic Medical Sciences

Qualifications & Specialty  

Obtained a bachelor’s degree in Applied Medical Sciences – Medical Laboratories from King Abdulaziz University in Saudi Arabia – Jeddah in 2009.

Besides that, Al-Habbab obtained a master’s degree in biology from the City University of New York in Brooklyn, USA in 2013.

Publications

Alhabbab has researched in her field

Research interests:

Biology, Genetics & Behavior   

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Sabah Mohamed Hassan

Lecturer of Biochemistry

Qualifications & Specialty  

Obtained a bachelor’s degree in Biochemistry from King Abdulaziz University in the Kingdom of Saudi Arabia in (2009)

Also obtained a master’s degree from King Abdulaziz University in the Kingdom of Saudi Arabia in (2014)

Publications

Hassan SM, Iyer AP, Al-Abbasi FA. (2016) Screening for Glucokinase (GCK) Gene Mutation in Gestational Diabetes Women in Western Region of Saudi Arabia, BJMMR. Vol 13(8): 1-10 DOI: 10.9734/BJMMR/2016/23928

Research Interest

Genetic mutations – gene expression – DNA sequencing – polymer chain reaction

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